Critical role of extracellular signal-regulated kinase phosphorylation on menadione (vitamin K3) induced growth inhibition
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منابع مشابه
Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation.
The vitamin K analog menadione (K3), capable of both redox cycling and arylating nucleophilic substrates by Michael addition, has been extensively studied as a model stress-inducing quinone in both cell culture and animal model systems. Exposure of keratin 8 (k-8) expressing human breast cancer cells (MCF7, T47D, SKBr3) to K3 (50-100 microM) induced rapid, sustained, and site-specific k-8 serin...
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Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac is associated with a decreased mortality from colorectal cancer. Sulindac causes regression of precancerous adenomatous polyps and inhibits the growth of cultured colon cell lines. Whereas induction of apoptotic cell death is thought to account for the growth inhibitory effect of sulindac, less is known ab...
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ژورنال
عنوان ژورنال: Cancer
سال: 2001
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(20010315)91:6<1156::aid-cncr1112>3.0.co;2-1